All modules, mandatory or optional, could be downloaded from this section. More detail on these modules and installation information are accessible in Support section.

Version 1.5

Proline Server

Proline server distribution contains Proline Server (the server Core module, Cortex), Proline Admin (for system administration purpose) and Sequence Repository (to gather proteins information from fasta files).

  • Windows Full Installer: Installs Proline Server modules and optionally PostgreSQL server (for Windows OS). Require administration rights
  • Windows Installer: Installs Proline Server modules (for Windows OS). PostgreSQL should already be installed, separately. No specific rights is require.
  • Archive file: Contains archives for Proline Server modules. For manual installation or for Linux.
Previous version could be accessible here

Proline Studio

Proline Studio, the rich client interface, is distributed in a Zip file that must be extracted on each client computer.

Previous version could be accessible here

Proline Web

Proline Web is the web client interface

  • Windows Installer: Installs the Proline Web application and optionally the MongoDB server.
  • Archive file: Contains the Proline Web application without its requirements.
Previous version could be accessible here


Contains utilities to be used in complement of Proline Suite.

RawToMzDB converter
See documentation or forum message for more information.

RawToMzDB: convert Thermo raw files into mzDB files. This is required for quantitative processing.

MS-Angel GUI
The MS-Angel Graphical User Interface can be used to define data processing workflows involving several steps such as file conversions, MS/MS searches, search results import in Proline, Proline results validation & quantification.
Important note: it is mandatory to first install the Proline Web extension (see above) to take advantage of the MS Angel tool.
You can find the MS-Angel documentation here.

 MS-Angel GUI: set up data processing workflows including Proline algorithms.

mzDB Wizard
This tool allows user to easily convert raw files to mzdb (for XIC quantitation) and upload them on server side. This application embed the recommended version of raw2mzdb converter.
You can find the mzDB Wizard documentation here.

mzDB Wizard: convert raw files into mzDB files and upload them on server side.


This application permits mzDB files visualization (chromatograms, scans, …). The corresponding documentation is available in the Proline User Guide (online here).

mzScope: see inside your mzDB files.

Tutorials data

Samples (2 μg of yeast cell lysate + different spiked levels of UPS1) were analyzed in triplicate by nanoLC–MS/MS on an LTQ-Orbitrap Velos mass spectrometer. For more information on samples preparation and LC-MS/MS analyses, please refer to Ramus et al., J Proteomics. 2016 Jan 30;132:51-62. doi: 10.1016/j.jprot.2015.11.011.

SAMPLE RAW File Mascot dat File mzDB File
2µg levure UPS1 100fmol- Replicat 1 OEMMA121101_61b.raw F083068.dat OEMMA121101_61b.mzdb
2µg levure UPS1 100fmol- Replicat 2 OEMMA121101_63b.raw F083069.dat OEMMA121101_63b.mzdb
2µg levure UPS1 100fmol- Replicat 3 OEMMA121101_65b.raw F083070.dat OEMMA121101_65b.mzdb
2µg levure UPS1 10fmol – Replicat 1 OEMMA121101_36b.raw F083064.dat OEMMA121101_36b.mzdb
2µg levure UPS1 10fmol – Replicat 2 OEMMA121101_38b.raw F083066.dat OEMMA121101_38b.mzdb
2µg levure UPS1 10fmol – Replicat 3 OEMMA121101_40b.raw F083067.dat OEMMA121101_40b.mzdb

Short protocol description:
Peaklist were generated using the Extract_msn.exe macro provided with Xcalibur. Peaklists were submitted to Mascot database searches (version 2.5.1). ESI-TRAP was chosen as the instrument, trypsin/P as the enzyme and 2 missed cleavages were allowed. Precursor and fragment mass error tolerances were set at 5 ppm and 0.8 Da, respectively. Peptide variable modifications allowed during the search were: acetyl (Protein N-ter), oxidation (M), whereas carbamidomethyl (C) was set as fixed modification. Databases used were yeast database from UniprotKB (S_cerevisiae_ 20121108.fasta, 7798 sequences), a compiled database containing the UPS1 human sequences (48 sequences) and the corresponding reversed databases in order to calculate FDR.

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